Research progress of biomarkers of drug-induced liver injury
LIU Xiao-qian
WU Wen-xiao
GENG Xing-chao
LI Bo
Abstract：Drug-induced liver injury (DILI) is the main cause of adverse drug reactions,and drug withdrawal or restrictions.Biomarkers are important tools for evaluating preclinical drug hepatotoxicity and clinical diagnosis of potential liver injury in patients.In recent years,with the rapid development of omics technology and the development of mechanism research of of liver injury,there were more and more reports on new DILI biomarkers.In this paper,recent advances in the research of DILI biomarkers at home and abroad were reviewed,which could provide references for better evaluation of the potential risk of hepatotoxicity and clinical diagnosis of liver injury.
Keywords：drug-induced liver injurybiomarkeromics technologymechanism of liver injury
Publication Date：2018-01-01
Online Publishing Date：2026-08-14(First online date of this platform, not the publication date of the document)
Pages：6( 47-52 )