Study on the optimization of cimetidine therapeutic scheme against irradiation in mice
LIU Yu-ming
HE Ying
ZHAO Yi-ning
YUAN Wei-hong
SHEN Xian-rong
Abstract：Objective:To evaluate the protective effects of cimetidine in mice which damaged by 60Co γ irradiation and find out the best treatment scheme of cimetidine.Methods:Mail C57 mice were randomly divided into ten groups (normal control group,model control group,and seven cimetidine groups) and cimetidine was administrated intragastrically with different schemes.Except the normal control group,C57 mice were received total body irradiation by 8.0 Gy 60Co γ-ray in single time irradiation (1.01 Gy· min-1).The survival rate and survival time were recorded.Results:The 30-day survival rate of model control group was 20％ and the 30-day survival rate of of group C,D,E,F,G,H,I,J was 70％,60％,90％,50％,90％,50％,40％,respectively.Conclusion:Cimetidine can protect mice against γirradiation.According to the clinical application of cimetidine,the treatment scheme of group D was best and worth being advocated.
Keywords：cimetidineradioprotectiondrug therapeutic scheme30-day survival rate
Publication Date：2018-01-01
Online Publishing Date：2026-08-14(First online date of this platform, not the publication date of the document)
Pages：4( 43-46 )