Efficacy of cyclosporine A eye drops combined with loteprednol eye drops in treatment of vernal keratoconjunctivitis
SHANG Qing-li
WANG Xin
MA Hong-lei
XU Man
Abstract：Objective:To investigate the clinical efficacy of cyclosporine A eye drops combined with loteprednol eye drops for treating vernal keratoconjunctivitis.Methods:Sixty vernal keratoconjunctivitis patients were randomly divided into test group (n =30) to receive cyclosporine A eye drops (qid,one droplet once) combined with loteprednol eye drops (tid,one droplet once) and control group (n =30) to receive loteprednol eye drops only (tid,one droplet once).The treatment course was 12 weeks.The efficacy was evaluated at week 4,8 and 12,respectively,based on clinical symptoms and vital signs.Results:The total scores of the test group and control group both showed decrease at week 4,with statistically significant difference (P ＜ 0.05).Despite decrease existed in the scores of both groups at week 8 and 12,there was no statistical difference (P ＞ 0.05,P ＞ 0.05).Conclusions:Local administration of cyclosporine A is effective for treating vernal keratoconjunctivitis.cyclosporine A may be topically used in combination with glucocorticosteroids for treating vernal keratoconjunctivitis to prevent the occurrence of complications.
Keywords：vernal keratoconjunctivitiscyclosporine Aloteprednol eye dropsefficacy
Publication Date：2017-01-01
Online Publishing Date：2026-08-14(First online date of this platform, not the publication date of the document)
Pages：4( 2960-2963 )