Preparation and release of huperzine A precursor liquid crystal formulations
GUO Si
ZHOU Meng-meng
PAN Qian-wen
LI Li
LIU Hong
LUO Liang
Abstract：Objective:To prepare huperzine A precursor liquid formulations and study the injection performance,morphological characteristics and in vitro release.Methods:In the huperzine A precursor liquid crystal formulations,glyceryl dioleate(GDO) and soybean phospholipid(SPC) were used as liquid crystal forming materials,and ethanol was used as solvent.Huperzine A was loaded as the main drug at different ratios.The viscosities of the formulations were measured as a function of shear rate using a rheometer.The morphological change of the formulations after hydration was measured by polarize microscopy;In vitro release rate was determined by HPLC.Results:Different ratios of huperzine A precursor liquid crystal formulation are all injectable;When fully absorbing water,the huperzine A precursor liquid crystal formulations with SPC∶ GDO =70∶30 and 60∶40 showed polarizing textures under polarized light,while other SPC∶ GDO ratios did not show any birefringence;The release of SPC∶ GDO =70∶30 huperzine A from the precursor liquid crystal formulation in pH 7.4 phosphate buffer solution (PBS pH 7.4 solution)lasted for over 168 h,with a cumulative release rate of above 90％.Conclusion:The precursor liquid crystal can be used as a long-acting drug delivery system for huperzine A.
Keywords：huperzine Asoybean phospholipidglyceryl dioleateanhydrous ethanolsustained release
Publication Date：2017-01-01
Online Publishing Date：2026-08-14(First online date of this platform, not the publication date of the document)
Pages：5( 2859-2863 )