Therapeutic effect, nerve function, CRP level analysis of butylphthalide and sodium chloride injection combined with edaravone in the treatment of new-onset cerebral infarction
YUAN Qing-fang
LI Xin-xin
ZHANG Jian-ping
DONG Wan-li
Abstract：Objective:To investigate the therapeutic effect,nerve function and CRP level of butylphthalide and sodium chloride injection (Enbipu) combined with edaravone on new-onset cerebral infarction.Methods:64 cases of new-onset cerebral infarction patients sequentially collected in Wuxi People's Hospital from May 2015 to February 2017.Those samples were equally split into testing group and control group according to the preset random number.The control group was treated by edaravone (30 mg,bid) for 10 days,while testing group was treated by edaravone (30 mg,bid) combined with Enbipu(100 mL,bid) with the same duration.The CRP level,nerve functions,daily life activities ability changes before and after treatment,the clinical curative effect and adverse reactions were observed.Results:After 10 d treatment,the CRP level of testing group was significantly lower than in the control group [(25.32±2.43) mg·L-1 vs (45.11 ±5.32) mg·L-1,P＜0.05].The NIHSS score of testing group was significantly lower than in the control group [(12.45 ± 2.31) points vs (16.32 ± 3.56) points,P ＜ 0.05],while BI score of testing group was significantly higher than in the control group [(80.32 ±7.15) points vs (50.87 ± 5.35) points,P ＜ 0.05].We also observed that the total curative rate of testing group was significantly higher than the control group [90.62％ (29/32) vs 53.12％ (17/32)] (P ＜ 0.05).Conclusion:The new-onset cerebral infarction patients can benefit from the treatment of Enbipu combined with edaravone,showing better improvement of nerve function and CRP level than edaravone alone.And Enbipu is considered as a safe and effective treatment on new-onset cerebral infarction patients.
Keywords：butylphthalide and sodium chloride injectionedaravonenew-onset cerebral infarctionnerve function
Publication Date：2017-01-01
Online Publishing Date：2026-08-14(First online date of this platform, not the publication date of the document)
Pages：4( 2818-2821 )