Advance of improvment of the prediction on cardiovascular toxicity in the drug development
WANG Ju-feng
Abstract：Cardiovascular risk remains a major reason that causes drug attrition during preclinical and clinical development,adverse drug reactions,and withdrawal from market.These tests of cardiac ion channels screening,action potential recording,and ECG monitoring by telemeter have improved the prediction for cardiac arrhythmia and decreased cardiac risk.However,there are still no better methods to monitor other cardiac toxicities,such as cardiac contractility,myocardial ischemia,and heart failure.Moreover,we have not paid enough attention to these cardiac toxicities compared to arrhythmia during drug development.This paper reviews the recent research progress,and comprehensive exposition of what is in the stage of drug development and clinical application of major cardiovascular risk,how to detect these risks,the existing safety assessment methods of accuracy and predictability,research and application of new methods and new technology.
Keywords：cardiovascular toxicityresearch and developmentcardiac arrhythmiaQT prolongationcardiac function
Publication Date：2017-01-01
Online Publishing Date：2026-08-14(First online date of this platform, not the publication date of the document)
Pages：6( 2753-2758 )