Effects of total flavonoids of Dracocephalummoldavica L· on learning and memory disorders of mice with dementia induced by D-galactose/sodium nitrite
ZHAI Wei
FAN Yan-hui
HU Yan-li
Abstract：Objective:To observe the effects of total flavonoids of Dracocephalummoldavica L.on D-galactose/ sodium nitrite-induced learning and memory disorders in mice.Methods:Sodium nitrite and D-galactose were subcutaneously injected for 60 days to induce dementia model in mice.The effect of total flavonoids of Dracocephalummoldavica L (25,50 and 100 mg· kg-1) on the learning and memory disorders in mice were evaluated by Morris water maze,and the levels of superoxide dismutase (SOD),malondialdehyde (MDA),glutathione peroxidase (GSH-Px),interleukin-1β (IL-1β),tumor necrosis factor-or (TNF-ct) and nitric oxide synthase (iNOS) in the cortex were measured.Results:Compared with the model group,treatment with total flavonoids from Dracocephalummoldavica L.significantly improved the learning and memory deficits induced by D-galactose/sodium nitrite;the dose of 50 mg· kg-1 decreased the expression of MDA and IL-1β;the dose of 100 mg·kg-1 could obviously down-regulate the activity of SOD,and up-regulated the expressions of MDA,IL-1β and TNF-α.Conclusion:Total flavonoids from Dracocephalummoldavica L.can improve the ability of learning and memory in dementia mice and the mechanism is probably related to resisting oxidation damage and inflammatory reaction.
Keywords：total flavonoids of Dracocephalummoldavica Ldementialearning and memory
Publication Date：2017-01-01
Online Publishing Date：2026-08-14(First online date of this platform, not the publication date of the document)
Pages：4( 2742-2745 )