Studies on the freeze-drying technics for furanodiene nanoemulsion
HUANG Xian
TAN Ding-yuan
CAI Chun-yan
WANG Dong-kai
Abstract：Objective:To prepare the freeze-dried furanodiene nanoemulsion and improve the stability of furanodiene nanoemulsion.Methods:Using freeze-drying process to prepare furanodiene nanoemulsion.The cryoprotectants and prescription technology of freeze-dried furanodiene nanoemulsion were optimized according to the appearance,dissolution status and particle size distribution.Results:The furanodiene nanoemulsion average size was (164.9±3.3) nm,and polydispersity index (PDI) was 0.157.After using 10％ sucrose as the cryoprotectant,the freeze-dried furanodiene nanoemulsion average size was(166.3 ± 7.9) nm,PDI was 0.163.The freeze-dried furanodiene nanoemulsion with a snow-white,smooth,plumpness appearance and with a short rehydrated time.Moreover,the particle size and main medicine were stable at 20 ℃.Conclusion:Lyophilized furanodiene nanoemulsion prepared with freeze-drying method is obviously more stable than furanodiene nanoemulsion.
Keywords：furanodienenanoemulsionfreeze-dryingcryoprotectantstability
Publication Date：2017-01-01
Online Publishing Date：2026-08-14(First online date of this platform, not the publication date of the document)
Pages：5( 2609-2613 )