Research advances in intracoronary thrombolysis for improving myocardial perfusion of patients with ST-segment elevation myocardial infarction
ZHU Wei-chao
QI Xiao-yong
DANG Yi
ZHANG Fei-fei
Abstract：ST-segment elevation myocardial infarction (STEMI) is a severe acute disease.The pathogenesis of STEMI is mostly attributed to the rupture or erosion of unstable intracoronary plaque,which even progress into thrombus leading to complete occlusion of coronary artery and result in myocardial ischemia eventually.Percutaneous coronary intervention (PCI) is known as a timely and effective way to open occlusion coronary artery.However,some patients showed poor myocardial perfusion after PCI,which may be ascribed to the thrombo-embolism on the level of microcirculation of infarction related artery.Previous clinical studies have indicated that intracoronary thrombolytic therapy can reduce thrombus burden and improve myocardial perfusion.With the development of new drugs,recombinant human prourokinase (rh-proUK),for example,the safety and effectiveness of intracoronary thrombolysis are further improved.In this review,we highlight the advances in coronary thrombolytic therapy in improving STEMI myocardial perfusion in recent years.
Keywords：ST-segment elevation myocardial infarctionpercutaneous coronary interventionintracoronary thrombolysisrh-proUK
Publication Date：2017-01-01
Online Publishing Date：2026-08-14(First online date of this platform, not the publication date of the document)
Pages：4( 2450-2453 )