Full factorial DOE optimizes the preparation process of topiramate pellets
MA Lin
WANG Wei
Abstract：Objective:To optimize the preparation process of topiramate pellets by extrusion and spheronization.Methods:The full factor experiment was carried out with MINITAB software to design 3 factor 2 level and 3 central points.The pellet yield (18 mesh to 30 mesh) and the average roundness coefficient were taken as the response value to study and optimize the process conditions.Results:According the model established by yield,the sphericity was 1 100 r·min-1,the loading capacity was 300 ～ 400 g,the sphericity was 2 ～3 min,the corresponding yield was over 87％,and the average roundness coefficient was over 0.77.Conclusion:The full factorial DOE has simply optimized the extrusion spheronization process.
Keywords：DOE full factorialextrusion-spheronizationMINITAByieldaverage roundness coefficient
Publication Date：2017-01-01
Online Publishing Date：2026-08-14(First online date of this platform, not the publication date of the document)
Pages：5( 2347-2351 )