In vitro deposition of ipratropium bromide aerosol determined with three different impactors: a comparative study
GAO Lei
WEI Ning-yi
ZHOU Ying
LIN Lan
NING Bao-ming
Abstract：Objective:To evaluate and compare the characters of ipratropium bromide aerosol in vitro deposition with three different impactors.Methods:To measure the particle size of ipratropium bromide with twin-stage impactor,ACI and NGI.Results:Using twin-stage impactor is simple,but it can only predict the deposition amounts of lung and throat.Although cascade impactor(CI) method is featured with complicated and time-consuming,it can not only acquire the fine particle dose,but also the aerodynamic particle size distribution of aerosol.Furthermore,the tests show that the methods of ACI and NGI have no significant difference and the wall loss of NGI is less than ACI.So,NGI is a better method than ACI.Conclusion:CI method is more scientific than TI method when evaluating the quality of aerosol.
Keywords：ipratropium bromideaerodynamic particle size distributionaerosoltwin-stage impingeAnderson cascade impactionnext generation cascade impaction
Publication Date：2017-01-01
Online Publishing Date：2026-08-14(First online date of this platform, not the publication date of the document)
Pages：5( 2319-2323 )