Molecular mechanism of mitochondrial dynamics regulation and its relationship with β-amyloid
YANG Han-yu
WANG Lu
ZANG Cai-xia
BAO Xiu-qi
ZHANG Dan
Abstract：Mitochondria are an important organelle which is always in the dynamic cycle of fission and fusion,and exerts normal functions through this process.The disruption of mitochondrial dynamic balance might lead to mitochondrial function disorders such as reduction of ATP production and accumulation of reactive oxygen species,which are associated with the etiology of Alzheimer's disease.β-Amyloid accumulation is an important pathologic feature of Alzheimer's disease.Studies have shown that 3-amyloid is involved in the regulation of mitochondrial dynamics.Therefore,studying the mechanism of mitochondrial fission and fusion as well as its relationship with β-amyloid may help us find a new direction for the treatment of Alzheimer's disease.In this review,we summarized the molecular mechanisms of mitochondrial dynamics and the relationship with β-amyloid,which might give new thoughts for new drug development.
Keywords：mitochondrial dynamicsAlzheimer's diseaseβ-amyloidfission and fusion
Publication Date：2017-01-01
Online Publishing Date：2026-08-14(First online date of this platform, not the publication date of the document)
Pages：6( 2285-2290 )