Absolute bioavailability of pazufloxacin mesilate capsule in healthy Chinese subjects
XIANG Jin
YU Qin
LIANG Mao-zhi
NAN Feng
QIN Yong-ping
Abstract：Objective:To develop an HPLC method for the absolute bioavailability of pazufloxacin mesilate capsule in healthy Chinese subjects.Methods:24 healthy male volunteers were enrolled in this study.Volunteers were divided into two groups and administered capsule and injection in cross-over randomized way.Determined the pazufloxacin concentration with HPLC method and calculated the pharmaokinetics parameters with WinNonlin program to evaluated the absolute bioavailability of pazufloxacin capsule.Results:The pharmacokinetic parameters following single oral dose of 300 mg pazufloxacin capsule and injection were as follows:the mean of Tmax were (0.60±0.23) and (0.50±0.00) h;the mean of Cmax were (5.09-±1.75) and (6.92±3.13) μg·mL-1;the mean of AUC(0-t) were (11.24 ±3.45) and (11.63 ±3.77) μg·mL-1·h;the mean of AUC(0-∞) were (11.58 ± 3.44) and (11.97 ± 3.77) μg· mL-1 · h;the mean of t1/2 was (2.37 ± 0.67) and (2.45 ± 0.82) h.Conclusion:The absolute bioavailability was 97.2％.
Keywords：pazufloxacinHPLCpharmacokineticsbioavailability
Publication Date：2017-01-01
Online Publishing Date：2026-08-14(First online date of this platform, not the publication date of the document)
Pages：4( 2209-2212 )