Effects of the property of solution medium on the solubility of asiaticoside

PENG Qian; CHEN You-quan; CAO Zi-zhen; YAN Shuai; XIONG Jin-ling; ZHANG Li; WANG Xiao-hui

Abstract：Objective:To study the effects of the property of solution medium on the solubility of asiaticoside,the equilibrium solubility of asiaticoside in different surfactants,cosurfactants and oils were investigated.Methods:The equilibrium solubility of asiaticoside in different surfactants,cosurfactants and oils were determined with HPLC,and the oil-water partition ratio of asiaticoside was determined by shake-flask method.Results:At 37 ℃,the equilibrium solubility of asiaticoside in glyceryl monolinoleate and caster oil were higher,which were 1 742.98 and 108.08 μg· mL-1,respectively.And the equilibrium solubility was poorly soluble in oleic acid,caprylic/ capric triglyceride,isopropyl palmitate,Labrafac Lipophile WL 1349 and isopropyl myristate.In the surfactants,the equilibrium solubility was the most dissolvability in Cremophor RH 40,which was 60 796.50 μg· mL-1.The equilibrium solubility was slightly soluble in Tween-20 and Tween-80.In the cosurfactants,Transcutol CG,Transcutol P and PEG-400 had more better solubility property and they were 79 477.24,67 492.32 and 41 091.48 μg·mL-1,respectively.The equilibrium solubility was sparingly soluble in 1,2-propanediol,slightly soluble in propanol,isopropanol,plurol oleique,glycerol and plurol isostearique.Conclusion:The study of equilibrium solubility of asiaticoside in different solution medium provides theoretical basis for further study of asiaticoside microemulsion and other formulations.