Novel therapeutic targets for the treatment of rheumatoid arthritis
SU You-rui
JI Ying-ying
GONG Guo-qing
Abstract：Rheumatoid arthritis (RA) is an autoimmune disease that leads to inflammation and destruction of synovial joints.Although many drugs for this heterogeneous disease have been discovered,30％ of patients still cannot be well controlled.Therefore,it is particularly important to find new therapeutic targets and develop new therapeutic drugs.Two pathways,named the Janus kinase (JAK) pathway and the T helper-17 (Th17) pathway,which are regarded as interesting novel therapeutic targets in the field of rheumatology,are discussed.The treatment potential of biologicals and the small-molecule inhibitors that can block these pathways are also reviewed in this paper.
Keywords：rheumatoid arthritis (RA)JAK-STAT pathwayIL-17-Th17 pathwaybiologicalssmall-molecule inhibitors
Publication Date：2017-01-01
Online Publishing Date：2026-08-14(First online date of this platform, not the publication date of the document)
Pages：7( 2019-2025 )