Effects of terpenes on percutaneous absorption of indomethacin-loaded liposome gel
ZHANG Hong-mei
ZHANG Zi-yi
CUI Bai-ji
SHI Nian-qiu
FENG Xian-min
Abstract：Objective:To prepare indomethacin liposome gel and investigate the effects of different absorption enhancers on its percutaneous absorption in vitro.Methods:The indomethacin liposome gel was prepared by thin-film dispersion method with Carbomer gelling agents.The effects of the mass ratios of phospholipid/ cholesterol and drug/phospholipid on indomethacin entrapment efficiency were investigated to optimize and choose the best formulation.And the effect of terpenes penetration enhancers on transdermal permeation of the drug was evaluated using improved Franz diffusion cells.Results:The mass ratios of liquid/cholesterol and drug/liquid for the best formation were 6∶1 and 1∶30,respectively.The preparation prepared using 4％ Carbomer showed desirable characteristics and appearance.Indomethacin liposome gel using 2.5％ fenchone showed the highest cumulative permeation amount (Q24) of (198.36±15.78) μg·cm-2 and fluxrate (Js) of (7.93 ±3.01) μg·cm-2·h-1 Conclusion:The highest cumulative permeation amount was obtained with fenchone 2.5％ for indomethacin liposome gel.Indomethacin liposome gel has good potential for transdermal delivery.
Keywords：indomethacinliposome gelpercutaneous absorptionpenetration enhancers
Publication Date：2017-01-01
Online Publishing Date：2026-08-14(First online date of this platform, not the publication date of the document)
Pages：4( 1938-1941 )