PD-1/PD-L1 pathway in the development and treatment of tumors: a review of literature
CHE Zhang-hong
Abstract：PD-1/PD-L1 pathway has been shown to play an immunosuppressive role in the activation and proliferation of T cells in vitro and in vivo.It has been confirmed that PD-1/PD-L1 is highly expressed in various tumor tissues such as melanoma,non-small cell lung cancer,liver cancer,lung cancer and kidney cancer,so as to form an immunosuppressive microenvironment and promote the occurrence,development,invasion and metastasis of tumors.Inhibitors targeting PD-1,such as pembrolizumab and atezolizumab,have been approved by the FDA for therapy of malignant melanoma and non-small cell lung cancer.In addition,atezolizumab,an inhibitor of PD-L1,is also undergoing clinical trials and expected to be used in cancer therapy in the near future.
Keywords：tumorimmunosuppressionPD-1PD-L1
Publication Date：2017-01-01
Online Publishing Date：2026-08-14(First online date of this platform, not the publication date of the document)
Pages：5( 1913-1917 )