Formulation optimization of propranolol hydrochloride gels by central composite design-response surface methodology and in vitro transdermal absorption test
GU Yong-wei
JIANG Lin-li
YANG Meng
XUE Chun-yu
LIU Ji-yong
Abstract：Objective:To optimize the formulation of propranolol hydrochloride gels for the treatment of infantile hemangioma.Methods:Poloxamer P407 was used as gel matrix with azone and propylene glycol as transdermal permeation enhancers for the preparation of propranolol hydrochloride gels.Central composite designresponse surface methodology was applied to optimize the proportions of azone and propylene glycol in the prescription according to the cumulative amount of permeation in vitro measured by Franz diffusion.The optimal prescription was verified finally.Results:4％ azone and 5％ propylene glycol were the optimal transdermal permeation enhancers of propranolol hydrochloride gels.The cumulative amount of permeation in vitro at 12 h was up to 1 377.81 μg·cm-2 Conclusion:The prescription of propranolol hydrochloride gels optimized by central composite design-response surface methodology is stable and the quality of the product is controllable.So it can provide a new administration route of propranolol in the treatment of infantile hemangiomat.
Keywords：hydrochloride propranololgelcentral composite design-response surface methodology
Publication Date：2017-01-01
Online Publishing Date：2026-08-14(First online date of this platform, not the publication date of the document)
Pages：5( 1827-1831 )