Physicochemical properties and percutaneous permeability in vitro of hydrocortisone stratum corneum lipids liposomes
ZHENG Xue-hua
YU Li-peng
YANG Jun
YANG Yue-hui
Abstract：Objective:To prepare hydrocortisone stratum corneum lipids liposomes,and investigate the physicochemical properties and percutaneous permeability in vitro.Methods:Ethanol injection method was used to prepare hydrocortisone stratum corneum lipids liposomes,and the morphology of liposomes was observed with transmission electron microscopy.The encapsulation efficiency was determined by glucan gel column chromatography.The pH value,particle size,Zeta potential,in vitro percutaneous permeability and drug content retained in skin were all investigated.Results:The liposomes were uniform and round.The particle size,Zeta potential and encapsulation efficiency of hydrocortisone stratum corneum lipids liposomes were (433.90 ± 30.71)nm,(-33.09 ±1.86) mV and (40.32 ± 1.56)％,respectively,and the pH value was (5.77 ±0.03).The steady penetration rate of hydrocortisone stratum corneum lipids liposomes was (10.87 ± 0.76) μg· cm-2.h-1,1.91 times of that of ordinary liposomes.The retention amount of drug in the skin after 12 h was (3.31 ± 0.15) μg· cm-2,significantly higher than ordinary liposomes.Conclusion:The developed hydrocortisone stratum corneum lipids liposomes,with simple preparation process,which can effectively promote the percutaneous penetration of hydrocortisone,provide reference for development of new transdermal preparations of hydrocortisone.
Keywords：hydrocortisonestratum corneum lipids liposomephysicochemical propertypercutaneous permeation
Publication Date：2017-01-01
Online Publishing Date：2026-08-14(First online date of this platform, not the publication date of the document)
Pages：5( 1822-1826 )