Regulatory effect of mannanglcopeptide on postoperative immune function in patients with malignant thoracic tumor
CHEN Xue-yu
ZHANG Neng-chong
YIN Zheng-xin
LI Cheng-qiang
CHEN Zhong-yuan
ZHU Liang-gang
Abstract：Objective:To evaluate the feasibility and effect of mannanglcopeptide on postoperative immunity index in patients with malignant tumor in thorax.Methods:A single center prospective randomized controlled clinical study was designed.A total of 154 patients with malignant tumor in thorax were randomly divided into treatment group (n =86) and control group (n =68).Mannanglcopeptide was sprayed on the surface of wound during operations and intravenously injected postoperatively.The blood sample was collected at the following time:the day before operation,and the first day,the third day and the seventh day after operation.The content of T-lymphocyte subgroups (CD3 +,CD4 +,CD8 +,CD4 +/CD8 +) were measured by flow cytometry.T-lymphocyte subgroups,extubation time,hospitalization time and postoperative complications in the patients of two groups were compared.Results:Mannanglcopeptide treatment significantly increased T-lymphocyte subgroups (CD3 +,CD4 +,CD8 +,CD4 +/CD8 +) on the seventh postoperative day.Extubation and hospitalization time were significantly less in treatment group than in control group.The postoperative pulmonary infection was lower in treatment group.Conclusion:Postoperative application of mannanglcopeptide improves the immune function in patients with malignant tumor in thorax,and has advantages in pulmonary infection with lower extubation and hospitalization time.
Keywords：mannanglcopeptideesophageal cancerlung cancerT-lymphocyte
Publication Date：2017-01-01
Online Publishing Date：2026-08-14(First online date of this platform, not the publication date of the document)
Pages：4( 1818-1821 )