Preparation of sustained release solid dispersion of α-lipoic acid and its dissolution rate in vitro
TANG Wei
PANG Jian-guo
ZHU Xing-yi
Abstract：Objective:To prepare sustained release solid dispersion of α-lipoic acid with the intention of extending the release time of α-lipoic acid and improving its bioavailability.Methods:The mechanical chemical technology and microenvironment pH control technology were used to prepare the sustained release solid dispersion.The condition of mechanical milling and the in vitro dissolution of the solid dispersion were investigated,and the changes of crystalline form in the solid dispersion were characterized by XRD.Results:The type and dosage of ethyl cellulose had a certain effect on the release of the sustained release solid dispersion,and EC-N50 was better than other types;HPMC-E3 had better effect on the regulation of the release rate than other types;when the pH regulator was Na2CO3,the solid dispersion had a better sustained release effect,the accumulative drug-release percentage at 12 h in vitro was over 95％;the optimum mechanical milling process condition was determined to be 100 r· min-1,1 h;XRD had proved the formation of solid dispersion.Conclusion:The solid dispersion using ethyl cellulose as the carrier exhibits obvious slow releasing effect in vitro.
Keywords：α-lipoic acidsustained release solid dispersionmechanical millingmicroenvironment pH controldissolution rate
Publication Date：2017-01-01
Online Publishing Date：2026-08-14(First online date of this platform, not the publication date of the document)
Pages：6( 1706-1711 )