Progress of potential drugs in non-alcohol fatty liver disease
HU Wen-yi
MA Xiao-hui
LI Xin-xin
ZHOU Wang-yi
SUN He
Abstract：Non-alcohol fatty liver disease (NAFLD) is an important public health problem in the 21st century.Increasingly,people are paying attention to NAFLD in China.The onset of NAFLD is closely related to Insulin resistance,Obesity,Type 2 diabetes and Hyperlipoidemia.The pathogenesis of NAFLD is complex and there is no effective medicine to treat it.At present,therapeutic drugs includes insulin sensitizing with improving insulin resistance,lipid-lowering drugs with regulating lipid metabolism,antioxidant drugs against oxidative stress and lipid per-oxidation,and drugs of repairing damaged liver hepatoprotective.But the process is not entirely reversible by these drugs.The vacancy of first-line drugs prompt people to pay more attention to new therapeutic targets.So the article will deal with a detailed review on the potential therapeutic targets and clinical trials of NAFLD.Hope that the study will give some suggestions and guidance to the new drug development of NAFLD.
Keywords：non-alcohol fatty liver diseasefarnesoid X receptorinsulin sensitizerlipid-loweringoxygen stress
Publication Date：2017-01-01
Online Publishing Date：2026-08-14(First online date of this platform, not the publication date of the document)
Pages：6( 1661-1666 )