Research progress of drugs for the treatment of LPS-induced acute lung injury
YU Zi-ru
DU Guan-hua
Abstract：Acute lung injury/Acute respiratory distress syndrome (ALI/ARDS) is a kind of disease with high clinical mortality.Among them,the percentage of ALI associated with Gram-negative bacteria infection is very high,the main pathogenic factor of which is endotoxin (LPS).The pathogenesis of ALI is so complex that there is no specific treatment drugs.Therefore,the research on the treatment of LPS-induced acute lung injury has been paid more and more attention.And new progress has been made in the areas of anti-inflammatory,anticoagulant,improving pulmonary edema and anti-oxidative stress.Some new drugs such as surfactant,protease activity inhibitors and atrial natriuretic peptide has also achieved some clinical success.In this article,we reviewed treatment drugs of LPS-induced lung injury,which will provide references for the researchers to develop new anti-ALI drugs.
Keywords：endotoxinacute lung injuryacute respiratory distress syndrometherapeutic drugs
Publication Date：2017-01-01
Online Publishing Date：2026-08-14(First online date of this platform, not the publication date of the document)
Pages：6( 1510-1515 )