Study on intestinal absorption kinetics of koumine in rats
SHI Dong-mei
SU Yan-ping
YU Chang-xi
Abstract：Objective:To investigate the intestinal absorption kinetics of koumine in rats.Methods:In situ single-pass perfusion method was used to study the effect of drug concentration,absorption site and pH of perfusion solution on the absorption of koumine.The concentration of koumine was determined by HPLC.Results:The absorption rates of koumine in duodenum,jejunum and ileum were not significantly different (P ＞ 0.05) and the intestinal absorption mechanism of koumine was passive diffusion.The concentration of koumine had no effect on its absorption,and the pH of perfusion solution had significant effect on it (P ＜ 0.05).Conclusion:Koumine is well adsorbed at all segments of intestine in rats where there is no special absorption site.Koumine is suitable to be developed as sustained-release preparation.
Keywords：kouminein situ single-pass perfusionintestine absorption kineticsHPLC
Publication Date：2017-01-01
Online Publishing Date：2026-08-14(First online date of this platform, not the publication date of the document)
Pages：5( 1450-1454 )