Determination of aerodynamic particle size distribution (APSD) profiles of salbutamol sulfate dry powder inhaler with three different technologies
ZHOU Ying
WEI Ning-yi
LIN Lan
NING Bao-ming
Abstract：Objective:Using three methods to study the aerodynamic particle size distribution (APSD) of salbutamol sulfate dry powder inhaler (DPI).To characterize and compare the APSD profiles determined with two-stage impactor (TSI),Andersen cascade impactor (ACI) and next generation impactor (NGI),respectively.Methods:The particle size of salbutamol sulfate DPI was measured by TSI,ACI and NGI methods,respectively.Results:Less than 6.4 micrometers aerodynamic diameter size can be analyzed using TSI with simply operation,however,accurate aerodynamic diameter distribution was unable to be achieved.Using ACI and NGI,fine particle drug doses with different size aerodynamic diameter,as well as aerodynamic diameter distribution can be evaluated,but the inter-stage deposition in ACI were found to be higher than that in NGI.Conclusion:ACI and NGI are more precise methods for assessment of the quality of DPI compared with TSI.
Keywords：dry powder inhalersalbutamol sulfateaerodynamic particle size distributiontwo-stage impactorAndersen cascade impactornext generation impactor
Publication Date：2017-01-01
Online Publishing Date：2026-08-14(First online date of this platform, not the publication date of the document)
Pages：5( 1428-1432 )