Advances in research of CDK9 and their inhibitors
YI Rui
YI Hong-hong
HU Gao-yun
LI Qian-bin
Abstract：Cyclin-dependent kinase 9 (CDK9) is a kind of Ser/Thr kinase,playing a crucial role in transcription regulation.Its activation can phosphorylate the C-teriminal domain of RNA polymerase-Ⅱ and some transcription regulations factors,in turn promote the elongation of transcription.Recently,studies show that CDK9 is associated with some pathological processes such as AIDs,cancer,inflammation.As such,CDK9 is expected to become a new therapeutic target for these diseases prevention and/or treatment.This review highlights the roles of CDK9 in these pathological processes and the research progress of CDK9 inhibitors,with the aim to provide a guidance for further research in CDK9 inhibitors.
Keywords：CDK9AIDscancerinflammationinhibitor
Publication Date：2017-01-01
Online Publishing Date：2026-08-14(First online date of this platform, not the publication date of the document)
Pages：8( 1390-1397 )