Clinical evaluation of linezolid and monitoring of adverse reactions in elderly patients

LI Jia; LUO Hui-min; FAN Yu-hua; CHEN Jie; CHEN Xiao

Abstract：Objective:To appraise the rationality of clinical use of linezolid in a general teaching hospital,as well as its efficacy and safety.Methods:A retrospective study was performed in elderly patients treated with LZD injection or tablets between January 2015 and December 2015 at a tertiary hospital in Guangzhou.The application of linezolid and the effective rate and incidence of adverse reactions (ADR) were analyzed,referring to the drug instruction and relevant guidelines.Results:Among the 55 patients included (65 ～94 years old),there were 45 cases for rational use (81.81％),10 cases unreasonable (18.18％);28 patients were cured (50.91％),14effected (25.45％),5improved (9.09％),while 8 invalid (14.54％).In 21 cases (38.18％)observed ADR after medication,19 suffered from thrombocytopenia (34.55％),white blood cell reduced in 4 cases (7.27 ％),hemoglobin decreased in 3 cases (5.45 ％),3 of nausea and vomiting (5.45 ％),2 of diarrhea (3.64％),1 of skin rash (1.82％),and 1 of lactic acidosis(1.82％).The incidence of thrombocytopenia in patients with ICU was significantly higher than that in non-ICU (P =0.038),but there was no statistical significance between different dosage forms (P =0.512).Conclusion:Linezolid is effective in the treatment on Gram-positive bacteria infections in the elderly patients.However,research shows that it has high rate of thrombocytopenia,especially in ICU,which worth more clinical attention in future practice.