Design, synthesis and in vitro anti-tumor activity of tetrahydroisoquinoline compounds
ZHU Pan-hu
ZHANG Yan-chun
LI Jia-ming
HUANG Wei-jun
WANG Yu-jun
ZHANG Yang
ZUO Jian
Abstract：Objective:To synthesize a series of new tetrahydroisoquinoline compounds and evaluate their anti-tumor activity.Methods:Twelve novel tetrahydroisoquinoline compounds were synthesized by utilizing 3,4-dimethoxyphenethylamine,a series of benzoic acid derivatives and cinnamic acid derivatives as starting materials,subsequently undergoing Bischler-Napieralski reaction,acylation,cyclization,reduction,and hydrolysis.In vitro anti-tumor activities were assessed with SRB reduction assay.Results:The structures of target compounds were characterized by MS,IR,1H NMR and 13C NMR.The results of in vitro anti-tumor activities showed that compound 9e exhibited potential inhibition on HT-29 tumor cell line,and 9f possessed moderate inhibition on HT-29 and HUVEC tumor cell lines.Conclusion:The novel tetrahydroisoquinoline compounds provide a possibility for further investigation.
Keywords：tetrahydroisoquinolineanti-tumorsynthesizein vitro evaluation
Publication Date：2017-01-01
Online Publishing Date：2026-08-14(First online date of this platform, not the publication date of the document)
Pages：7( 1301-1307 )