Effect of portulaca oleracea polysaccharide on immunological function in mice with cyclophosphamide-induced immunosuppression
MENG Xiang-le
XUE Lei
ZHANG Zhen-wei
GUI Xin-jing
CHEN Yu-huan
TANG Jin-fa
LI Wei-xia
CAO Ying-jie
ZHAO Ya
LI Xue-lin
Abstract：Objective:To investigate the effect of portulaca oleracea polysaccharide (POP) on immunologic function in immunosuppressed mice and the possible mechanism.Methods:The immunosuppression was induced by cyclophosphamide (CTX) in mice.POP (180 and 90 mg· kg-1) and the positive control agent lentinan (100 mg·kg-1) were orally administered,respectively.Thymus and spleen indexes were determined.Proliferation of T and B lymphocytes was measured by MTT assay.IL-2,IL-4,IL-10,and IFN-γ in the serum were measured by ELISA.Results:POP enhanced the activity of NK and LAK cells,and significantly increased the levels of IL-2,IL-4,IL-10,and IFN-γ in serum.It also increased the index of thymus and spleen.Conclusion:POP improves immunosuppression and myelosuppression caused by CTX in mice,thus may alleviate the side effects of chemotherapy.This effect may be an improtant antitumor mechanism of POP.
Keywords：portulaca oleracea polysaccharideimmunosuppressionimmunosuppression cytokines
Publication Date：2017-01-01
Online Publishing Date：2026-08-14(First online date of this platform, not the publication date of the document)
Pages：5( 1296-1300 )