Research progress of isocitrate dehydrogenase inhibitors
WANG Huan-yu
ZHAO Ye
LIU Xiang-kui
Abstract：Isocitrate dehydrogenase (IDH) catalyzes the conversion of isocitrate to α-ketoglutarate (α-KG).However,mutant IDH can convert α-KG to the oncometabolite D-2-hydroxyglutarate (D-2HG),leading to DNA or histone hypermethylation.IDH inhibitors can decrease the level of D-2HG,induce histone demethylation,and finally inhibit tumor development.In this paper,the structure,mechanism,and clinical trials of IDH inhibitors were reviewed in the general.
Keywords：mutant isocitrate dehydrogenase (mIDH)D-2-hydroxyglutarate (D-2HG)hypermethylationIDH inhibitors
Publication Date：2017-01-01
Online Publishing Date：2026-08-14(First online date of this platform, not the publication date of the document)
Pages：7( 1272-1278 )