Preparation and quality evaluation of pH-sensitive chrysophanol liposomes
GENG Li-li
SUI Lin
ZHANG Peng-mei
LU Guo-sheng
ZHAO Zi-bing
WANG Yong-li
Abstract：Objective:To study the preparation method and quality evaluation of pH-sensitive chrysophanol liposomes.Methods:The pH-sensitive liposomes modified with CMCS were prepared by film-ultrasonic dispersion method,then the entrapment efficiency,SEM,particle size distribution,Zeta potential and stability were studied.Results:The optimal formulation was as follows:the hydration medium was Tris buffer,the concentration of CMCS was 0.2％ (W/V),the adding method was external addition,and the modification time was 30 min.Under this condition,the entrapment efficiency was (83.73 ± 1.57)％,the uniform particle size was (494.6 ± 9.6) nm,and the zeta potential was(-47.60 ± 1.08) mV.Conclusion:The pH-sensitive liposomes with CMCS modification prepared by film-ultrasonic dispersion method have relatively high entrapment efficiency,with good stability and uniform size distribution,and are sensitive to pH value.
Keywords：carboxymethyl chitosanchrysophanolpH-sensitive liposomesentrapment efficiency
Publication Date：2017-01-01
Online Publishing Date：2026-08-14(First online date of this platform, not the publication date of the document)
Pages：5( 1189-1193 )