Discussion on the influencing factors of Eudragit(R) NE 30D on the stability of drug release
LIU Chang-tao
LI Shu-ying
HE Shu-wang
WANG Wen-sheng
SHI Da-yong
LAN Yi
Abstract：Eudragit(R) NE 30D,which is commonly used as a sustained release coating and matrix and taste masking material,has a wide application in the pharmaceutical preparations.The formation of film coatings from the aqueous polymer dispersions is a complex process,highly dependent on additives and process parameters.Release instability of modified release coatings from aqueous polymer dispersions,which is known as physical aging,is a frequently described problem that hinders the general application of such dispersions.Based on the film formation mechanism from aqueous dispersions and the relevant literature reports,the present paper reviewed the technical methods to solve or prevent the physical aging of Eudragit(R) NE 30D,which would facilitate the application of the material in pharmaceutical preparations,especially the sustained controlled preparations and taste masking.
Keywords：Eudragit(R) NE 30Dphysical agingdrug releasestability
Publication Date：2017-01-01
Online Publishing Date：2026-08-14(First online date of this platform, not the publication date of the document)
Pages：5( 1180-1184 )