Synthesis and anti-tumor activity of novel asiatic acid A ring-cleavage derivatives in vitro
MENG Yan-qiu
ZHANG Wei-chen
NING Zi-ting
LU Xue-yu
YANG Li-na
Abstract：Objective:To design and synthesize asiatic acid (AA) derivatives modified in ring-A,C-23 and C-28,and study the anti-tumor activities in vitro.Methods:Asiatic acid was used as the leading compound to synthesize 2,3-oxo-des-A-23-hydroxyl (acetyl)-urs-12-ene-28-ester through structural modification at C-2,C-3,hydroxyl of C-23,and carboxyl of C-28 respectively.The anti-tumor activities of the synthesized compounds against SGC-7901 and A549 were evaluated by MTT assay.Results:The structures have been verified by MS and 1HNMR.Conclusion:The MTT assay indicated that these compounds showed more potent inhibitory activity on the tumor cells than that of the parent compound AA,and the inhibition rates of compound g and k were better than gefitinib.The derivatives are worthy to be studied further.
Keywords：asiatic acidsynthesisanti-tumor activity
Publication Date：2017-01-01
Online Publishing Date：2026-08-14(First online date of this platform, not the publication date of the document)
Pages：6( 1157-1162 )