Protein-protein interaction: a novel direction for discovering anti-tumor drugs
JIANG Yong-lin
JIANG Zheng-yu
YOU Qi-dong
Abstract：The progress of cancer genomics,targeted therapy and tumor biology has confirmed the important role of protein-protein interaction (PPI) in tumorigenesis,providing another new approach for developing anti-tumor drugs.However,there are some challenges in the discovery of PPI inhibitors,such as large interface,shallow pockets.Recently,the theory of "hotspot" has been put forward,providing an innovative method for the discovery of PPI inhibitors.The emerging drug design strategies,including peptidomimetic design and fragmentbased screening,further enriched the technical means for discovery of PPI inhibitors.The target validation,drug design and clinical research together accelerate the development of PPI-based drug design,which will further promote the development of individualized medicine for oncotherapy.This review systematically illustrated the strategies for discovering PPI-based drugs,and briefly introduced some popular antitumor targets,such as MDM2/p53,IAP and Bcl-2.
Keywords：protein-protein interactionanti-tumorsmall molecule drug
Publication Date：2017-01-01
Online Publishing Date：2026-08-14(First online date of this platform, not the publication date of the document)
Pages：11( 1119-1129 )