Application of differential scanning calorimetry in the purity analysis of chemical reference substances
LIU Yi
WU Jian-min
LU Juan
LI Yu-wei
NING Bao-ming
LIN Lan
Abstract：Objective:To introduce the application of differential scanning calorimetry (DSC) in the purity analysis of chemical reference substances such as phenazone and propyphenazone.Methods:The DSC method,high performance liquid chromatography (HPLC) and volumetric method were used to analyze the values of chemical reference substances,and the applicability of DSC was also studied by means of thermogravimetric analysis (TGA).Results:The purities of phenazone and propyphenazone determined by DSC analysis,HPLC analysis and volumetric analysis were 99.9％ and 99.7％,100.0％ and 100.0％,100.2％ and 100.2％,respectively,without significant differences.Conclusion:Differential scanning calorimetry is particularly suitable for purity analysis of chemical reference substances,and this study would actively promote the application of thermal analysis technology in the field of drug control.
Keywords：differential scanning calorimetry (DSC)thermogravimetric analysis (TGA)chemical reference substancethermal analysis
Publication Date：2017-01-01
Online Publishing Date：2026-08-14(First online date of this platform, not the publication date of the document)
Pages：4( 1115-1118 )