The effect of a novel isofiavonoid derivative J37941 on scopolamine-induced learning and memory deficits in mice
WANG Zhe
FENG Zhang-ying
ZHOU Wei
PANG Xiao-cong
LIAN Wen-wen
WU Song
LIU Ai-lin
DU Guan-hua
Abstract：Objective:To investigate the effect of compound J39136,an isoflavonoid derivative with acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) inhibitory activities,on learning and memory impairment induced by scopolamine and to provide data basis for in-depth study of this compound.Methods:Step-down and step-through passive avoidance tests and Morris water maze test were used to evaluate the effect of J39136 on cognitive impairments in mice.Results:J39136administration reversed scopolamine-induced cognitive deficits in the passive avoidance tests,significantly increased step-down latency and reduced step-down error times.The escape latency during training in the Morris water maze test was reduced significantly as well.There is certain correlation between the effect and dose.Conclusion:J39136 can ameliorate cognitive deficits induced by scopolamine and it deserves further study.
Keywords：J39136Alzheimer's diseaseacetylcholinesterase (AChE)butyrylcholinesterase (BuChE)scopolamine
Publication Date：2017-01-01
Online Publishing Date：2026-08-14(First online date of this platform, not the publication date of the document)
Pages：5( 1110-1114 )