Clinical efficacy of bacillus subtilis combined with standard triple therapy for Helicobacter pylori infection

WANG Ying; WANG Xiao-hui; YAN Zhi-hui; LI Chao; HE Xing; LUO Zhe; GONG San-dong; CUI Li-hong

Abstract：Objective:To evaluate the clinical efficacy and value of adjuvant treatment of Helicobacter pylori (Hp) infection with bacillus subtilis.Methods:267 patients from outpatient or ward of department of gastroenterology in our hospital were enrolled in this experiment from April 2014 to March 2017.All the patients were confirmed to have functional dyspepsia and Hp infection.We excluded the patients who had taken the drugs that may influence this study observation or had a history of Hp infection but took failed eradication therapy.All patients were divided into two groups randomly,the control group and the study group.The patients in the control group took the following drugs for 2 weeks,the amoxicillin and clavulanate potassium tablets,the clarithromycin tablet and the pantoprazole enteric-coated tablets.The patients in the study group took the following drugs for 2 weeks,the live combined bacillus subtilis and enterococcus faecium enteric-coated capsules,the amoxicillin and clavulanate potassium tablets,the clarithromycin tablet and the pantoprazole enteric-coated tablets.After 2 weeks,all the patients stopped taking all the drugs.6 weeks later,all the patients were evaluated whether Hp had been eradicated successfully by 13C-UBT.We recorded the adverse reactions at the 1st week and the 2nd week.Hp eradication rate and the adverse reaction rate were compared between the two groups.Results:The total eradication rate of the study group which was added live combined bacillus subtilis and enterococcus faecium enteric-coated capsules was 89.6％,which was significantly higher than the control group (76.5％,P ＜ 0.05).The adverse reaction rate in the study group(6.7％)was significantly lower than that of the control group(18.9％,P ＜0.05).Conclusion:The live combined bacillus subtilis and enterococcus faecium enteric-coated capsules combined triple therapy can improve the eradication rate of Hp,reduce the incidence of adverse reactions,and improve the eradication effect of Hp.