The research progress of the elderly schizophrenia using paliperidone extended-release tablets
CAI Qing-yan
ZHANG Lan
JIAN Wei
Abstract：Paliperidone extended-release(ER) tablets is a relatively new atypical antipsychotic drug,which plays a role of antipsychotie therapy through antagonism of D2 receptor and 5-HT2A receptor,as well as strong blocking effect of D3 receptor and 5-HT7 receptor,so as to improve cognitive function and solve sleeping problems in patients.In recent years,paliperidone ER has been widely used in clinical practice,and it has obvious advantages in the treatment of schizophrenia in elderly patients.This paper briefly explained the specificity of drug selection in elderly patients with mental disorders,the pharmacological characteristics of paliperidone ER and its effects on blood glucose,blood lipid,prolactin and body weight,and compared the efficacy and safety of paliperidone ER with other antipsychotic drug.On the basis of previous research and the latest research evidence and clinical experience,the clinical efficacy and safety of paliperidone ER in elderly patients with schizophrenia were mainly reviewed.
Keywords：elderly schizophreniapaliperidone extended-release tabletsefficacysafety
Publication Date：2017-01-01
Online Publishing Date：2026-08-14(First online date of this platform, not the publication date of the document)
Pages：5( 1029-1033 )