Exploration of preparation technology of Curcumin liquid crystalline nanoparticles suitable for scale amplification
GOU Zi-jie
DENG Sheng-qi
TAO Jing
ZHENG Qin
ZHANG Yi-bin
Abstract：Objective:To prepare curcumin liquid crystalline nanoparticles (Cur-LCN),and identify the optimum prescription and preparation technology suitable for scale amplification.Methods:Bottom-up method was selected for the preparation of Cur-LCN,and the entrapment efficiency of Cur-LCN was evaluated using dialysis method and HPLC method.The optimum prescription was determined by single factor test and orthogonal test design.Next,the influences of stirring time,ultrasonic power and other factors on the entrapment efficiency of Cur-LCN were investigated,and then the preparation technology suitable for scale amplification was identified.Results:Using the optimum prescription and preparation technology,the entrapment efficiency of Cur-LCN after scale amplification could reach (86-± 2)％.Conclusion:The preparation technology and optimum prescription determined in this experiment is reasonable and reliable,and it is suitable for scale amplification.
Keywords：preparation technologyliquid crystalline nanoparticlesCurcuminscale amplification
Publication Date：2017-01-01
Online Publishing Date：2026-08-14(First online date of this platform, not the publication date of the document)
Pages：6( 946-951 )