Dl-3-n-butylphthalide protects hippocampal mitochondria in rats with epilepsy
ZHENG Zhao-shi
CAO Xiao-shuai
ZHANG Jing
WU Yi-ran
LI Xin-xin
LIU Song-yan
Abstract：Objective:To explore the protective effect of dl-3-n-butylphtalide (NBP) on hippocampal mitochondria in rats with epilepsy.Methods:① The kindling model was induced by pentylenetetrazol in rats.② The activity of mitochondrial respiratory chain complexes Ⅱ and Ⅳ in the hippocampus was determined by colorimetric method.③ The mitochondrial ultrastructure of the hippocampal CA3 region was observed by transmission electron microscopy.④ The electrical activity of hippocampal CA3 region was recorded using BL-420 Stereotaxic apparatus.Results:Compared with epileptic control,dl-3-n-butylphthalide significantly improved activity of the mitochondrial respiratory chain complex Ⅳ (P ＜ 0.01),attenuated the damage degree of mitochondrial ultrastructure,and reduced the frequency of electrical explosive activity in hippocampal cells in CA3 region.Conclusion:D1-3-n-butylphthalide has a protective effect on hippocampal mitochondrial function in epileptic rats,which can reduce the electrical activity of epilepsy in hippocampal CA3 region,and may be used as an adjuvant treatment of epilepsy.
Keywords：epilepsydl-3-n-butylphthalidemitochondria
Publication Date：2017-01-01
Online Publishing Date：2026-08-14(First online date of this platform, not the publication date of the document)
Pages：5( 808-812 )