Evaluation of imipenem dosing regimens for patients with severe burn infection
LI Na
ZHU Li-qin
LIU Wei
GE Ting-yue
XU Gao-qi
LIAO Sha-sha
Abstract：Objective:To evaluate and optimize different dosage regimens of imipenem for severe burn infections.Methods:Cumulative fraction of response (CFR) obtained by Monte Carlo simulation (MCS) were used to evaluate the effect of imipenem dosage regimens.Setting ％ T ＞ 4MIC above 40％ and obtaining CFR of different dosage regimens,the best dosage regimen would be recommended according to CFR.Results:The CFRs of imipenem 500 mg q6h,1 000 mg q8h and 1 000 mg q6h,iv for 3 h,were more than 90％ for severe burn patients infected with Escherichia coli and Klebsiella pneumonia.Taking into account the clinical practice and patient compliance,the optimal dosage regimen of imipenem was 500 mg q6h iv for 3 h.Since CFR of imipenem dosing regimens were less than 90％ for severe burn patients infected with Pseudomonas aeruginosa and Acinetobacter baumannii,combined medication was thereby recommended.Conclusion:When imipenem is prescribed for severe burn infections and the daily dosage is fixed,increasing the dosing frequency and prolonging the infusion time can improve the clinical outcome.
Keywords：imipenemburn infectionpharmacokinetics/pharmacodynamicsGram-negative bacterium
Publication Date：2017-01-01
Online Publishing Date：2026-08-14(First online date of this platform, not the publication date of the document)
Pages：4( 787-790 )