Antitussive, expectorant and anti-inflammatory effects of butylphthalide in mice
WANG Zhi-wang
FU Xiao-yan
REN Yuan
WANG Yong-hui
LIN Xing-yao
WANG Rui-qiong
Abstract：Objective:To investigate the antitussive,expectorant and anti-inflammatory effects of butylphthalide in mice.Methods:Mice were divided into butylphthalide (0.2,0.1,0.05 g·kg-1) and control groups.Cough latent period and cough times,phenol red secretion,swelling degree of ear and foot,and the levels of total protein and tumor necrosis factor-α (TNF-α) in synovitis of exudates were measured.Results:Butylphthalide at a dose of 0.2 g·kg-1 could prolong cough latent period,reduce cough times,promote the secretion of phenol red and depress the levels of TNF-α in synovitis of exudates (P ＜ 0.05).Butylphthalide could depress the swelling degree of ear at the doses of 0.1 and 0.2 g· kg-1,depress the swelling degree of foot and the levels of total protein in synovitis of exudates at the doses of 0.05,0.1 and 0.2 g· kg-1 and decrease the level of TNF-α in synovitis of exudates at the dose of 0.2 g· kg-1 (p ＜ 0.05,P ＜ 0.01).Conclusion:Butylphthalide has good antiinflammatory effect and certain antitussive and expectorant effects.The anti-inflammatory effect of butylphthalide may be one of its mechanisms of antitussive and expectorant effects.
Keywords：butylphthalideantitussiveexpectorantanti-inflammatoryTNF-α
Publication Date：2017-01-01
Online Publishing Date：2026-08-14(First online date of this platform, not the publication date of the document)
Pages：5( 675-679 )