Study on the pharmacokinetics of flupirtine maleate dropping pills

L(U) Xiao-min; SUN Cheng; WANG Dong-dong; ZHANG Hui-kao; HU Rong

Abstract：Objective:To study the relative bioavailability and bioequivalence of flupirtine maleate sustainedrelease dropping pills and flupirtine maleate commercial capsules.Methods:SD rats were used as experimental animals,high performance liquid chromatography was used to determine the plasma concentrations in rats after given single oral dose of the flupirtine maleate sustained-release dropping pills and commercial capsules.Pharmacokinetic parameters were calculated with DAS 2.0 software.Results:The main pharmacokinetic parameters for flupirtine maleate sustained-release dropping pills and commercial capsules were as follows:Tmax (3.400 ± 0.548) and (2.200±0.447) h;Cmax (3.996 ± 0.199) and (3.236±0.141) μg·mL-1 In peak time at T2.2h of capsules,the Cmax of drop pill is far greater than Cmax of capsules;AUC0～∞ (48 503 ± 2.749) and (33.889 ± 3.195) μg· mL-1 · h;MRT (9.212 ± 1.752) and (7.160 ± 0.563) h,respectively.The mean relative bioavailability of flupirtine maleate sustained-release dropping pills to capsules was (144.388 ± 18.400)％.Conclusion:At the same dose,the flupirtine maleate dropping pills were more excellent in bioavailability and absorption than capsules.The results can provide reference for the pharmacodynamic experiment of flupirtine maleate dropping pills and the research of sustained-release preparations.