New synthetic process of clofarabine
CHENG Zhi-gang
CHEN Liang
WANG Xu-dong
WANG Yan-ping
HAN Jiao
DAI Xu-yong
Abstract：Objective:To develop a new non-infringing synthetic process of clofarabine.Methods:After bromination,2-deoxy-2-fluoro-1,3,5-tri-O-benzoyl-α-D-ribofuranose (2) was reacted with 2,6-dichloropurine to get coupling product,and the clofarabine was obtained after methanolysis of the coupling product.Results:A new coupling method with reliable quality and stable yield was developed,the structure of clofarabine was identified with MS,1HNMR and 13CNMR.Conclusion:The new non-infringing synthetic process is simple and easy to operate,and is suitable for the industrial production.
Keywords：clofarabinenew processsilylationsynthesis
Publication Date：2017-01-01
Online Publishing Date：2026-08-14(First online date of this platform, not the publication date of the document)
Pages：3( 570-572 )