The mechanism of caninal IKKα and IKKβ in insulin resistance and type 2 diabetes mellitus as well as drug therapy
YU Mei-xia
LIU Xun
DU Liu-tao
NI Jian
ZHOU Yong-ming
Abstract：Insulin resistance,obesity and type 2 diabetes mellitus are closely related with the chronic inflammation.Proflammation such as tumor necrosis-α,TNF-α and interleukin-6,IL-6 leads to insulin resistance,obesity and type 2 diabetes mellitus through the activity of canonical IKKα,IKKβ and noncanonical IKKα,IKKβ pathway to activate NF-κB pathway.IKKβ plays a leading role in the canonical IKKα and IKKβ.Inhibiting IKKα and IKKβ can reduce the inflammation significantly,improves insulin sensitivity,decreases body weights and type 2 insulin mellitus.IKKα and IKKβ pathway is a new target for treating insulin,obesity and type 2 diabetes mellitus.
Keywords：IKKαIKKβinsulin resistancetype 2 diabetes mellitusdrug therapy
Publication Date：2017-01-01
Online Publishing Date：2026-08-14(First online date of this platform, not the publication date of the document)
Pages：7( 535-541 )