Adefovir dipivoxil-induced Fanconi syndrome: a retrospective analysis of 77 cases
WANG Jun-na
HUANG Wen-xiang
Abstract：Objective:To study the clinical characteristics of adefovir dipivoxil-induced Fanconi syndrome and provide reference for rational drug use in clinic.Methods:By retrieving CNKI and PubMed during 2010-2015,a total of 40 papers involving 77 cases of Fanconi syndrome were collected and analyzed retrospectively.Results:Long-term use of adefovir dipivoxil at low-dose to treat hepatitis B might cause Fanconi syndrome,the main clinical manifestation was bone pain,accompanied with hypophosphatemia,renal glycosuria,and albuminuria.Conclusion:To ensure medication safety,the patients who would take adefovir dipivoxil for a long time should be monitored for blood electrolyte,urine routine,and ALP,and have imageological examination periodically and visit the clinic in time when adverse drug reactions occur.
Keywords：adefovir dipivoxilFanconi syndromeretrospective analysis
Publication Date：2016-01-01
Online Publishing Date：2026-08-14(First online date of this platform, not the publication date of the document)