Case report and literature analysis of anaphylactic shock induced by succinylated gelatin
LIU Hong
SHI Rui
LI Ran
MA Xu
ZHANG Yan-hua
Abstract：Objective:To investigate the serious adverse reactions induced by succinylated gelatin infusion in recent years.Methods:We reported here a case of anaphylactic shock induced by succinylated gelatin infusion during operation.CNKI and PubMed databases were searched with key words " gelatin succinylated"," severe adverse effect",and " anaphylactic shock".Results:Twenty-four cases of allergic reactions and anaphylactic shock were retrieved and no death occurred,among which 17 cases continued surgery.Anaphylactic shock caused by succinylated gelatin was more common in male patients.The median onset time of anaphylactic reactions was 30 min after infusion,and relieved within 0.5 ～ 48 h.Some patients had an allergy history to drugs or food.Conclusion:Patients with allergic history to gelatin and meat products should be monitored with caution while infusion.For high risk population,skin test screening could be considered.Rescue therapy should be prepared in advance in case of anaphylactic reaction during operation.
Keywords：succinylated gelatinanaphylactic shocksevere adverse drug reaction
Publication Date：2016-01-01
Online Publishing Date：2026-08-14(First online date of this platform, not the publication date of the document)