The new direction in the development of antibiotics:anti-bacterial antibody drugs
WANG Zhi-ming
Abstract：Because of the increasing incidence of antibiotic resistance and long term negative effects on human health of broad-spectrum antibiotics,development of antibiotics with different therapeutic mechanisms has become an urgent topic for human to maintain health.The targeting effect and high efficiency of antibody drugs have come into people's view.There are many anti-bacterial antibody drugs in development,including raxibacumab for the treatment of inhalation anthrax,which is already on the market,and antibody drugs for the treatment of Staphylococcus aureus and Pseudomonas aeruginosa infections,which are representative of the next generation of mAbs that are in clinical or preclinical stage.The antibacterial antibody drugs under research usually target material basis of the invasion force of pathogenic bacteria and related toxins.Antibody engineering technology,such as genetically engineered mice,antibody library,human B cells hybridoma and the single B cell antibody technology,is in rapid development and plays an important role in promoting the R&D of antibacterial antibodies.Antibody drugs will become a kind of precise targeting treatment of bacterial infections and contribute to human health.
Keywords：antibiotic resistancebroad-spectrum antibioticsantibody drugstargeted therapygenetically engineered micehuman B cells hybridoma technology
Publication Date：2016-01-01
Online Publishing Date：2026-08-14(First online date of this platform, not the publication date of the document)