Pharmacokinetics and relative bioavailability of indapamide controlled release tablets in Beagle dogs
LIU Xiao-juan
NIE Shu-fang
PAN Wei-san
SUN Yu-qi
LIU Wen-tao
Abstract：Objective: To study the pharmacokinetics and relative bioavailability of indapamide controlled release tablets in healthy Beagle dogs. Methods; Indapamide controlled release tablets (test product) and indapamide sustained release tablets (reference product) were given orally to six healthy Beagle dogs by a two-crossover design. Indapamide concentrations in plasma were determined by HPLC-MS and the plasma concentration-time curves were plotted. The pharmacokinetic parameters and relative bioavailability were calculated and evaluated u-sing statistic computer program. Results; The concentration-time curve of indapamide controlled release tablets was similar to that of indapamide sustained release tablets, and their t_(1/2) were (11.71 ±1.69) and (11. 87 ±1.72) h, C_(max) were (87.17±22.03) and (87. 64±24. 24) μg·L~(-1), T_(max) were (6.67±0.52) and (6.83±0.75) h, AUC_(0-48h) were (1200.31 ±577.16) and (1162.53±463. 85) μg·h·L~(-1) ,AUC(0～∞) were (1 276.73 ±619. 22) and (1 250.20 ±507.63) μg·h·L~(-1), respectively. According to AUC_(0～48h), the relative bioavailability of indapamide controlled release tablets was (101.0±17.7)%. Conclusion: Compared with the sustained release tablets , indapamide controlled release tablets have similar pharmacokinetic profile and bioavailability.
Keywords：indapamide controlled release tabletHPLC-MSpharmacokineticsrelative bioavailability
Publication Date：2010-01-01
Online Publishing Date：2026-08-14(First online date of this platform, not the publication date of the document)