Inhibitory effects of 10 flavonoid glycosides on the pathways of diabetic pathogenesis
CHENG Li-yan
SHI Hong
Abstract：Objective: To estimate the inhibitory effects of 10 flavonoid glycosides on the 4 important pathways in diabetic pathogenesis, and to find new and effective extracts of Chinese herbs for treatment of diabetes. Methods: Semi-purified protein kinase C ( PKC) was extracted from brains of normal rats, and crude aldose reduc-tase (AR) was from kidneys. Malondialdehyde (MDA) was produced by activating brain tissue with Fenton reagent. Advanced glycation end products (AGEs) were synthetized in vitro. The effects of flavonoid glycosides (1 mg·mL~(-1)) on the enzymes or their products were observed. Results; Baicalin and breviscapine showed inhibitory effects on AR, PKC, AGEs and MDA with different degrees of activity. Conclusion; Among 10 flavonoid glycosides , baicalin and breviscapine have potentially preventing effects for diabetic pathogenesis by inhibiting the 4 important pathways.
Keywords：active flavanoiddiabetescomplication
Publication Date：2010-01-01
Online Publishing Date：2026-08-14(First online date of this platform, not the publication date of the document)